Publications

Underline denotes Busada lab members.

Duncan BC, Morris MT, Pascoe JL, Khadka S, Wang L, Hu G, Busada JT. Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atrophy bioRxiv 2025.03.14.643321; doi: 10.1101/2025.03.14.643321

Morris MT, Pascoe JL, Busada JT. In vitro to in vivo evidence for chemical disruption of glucocorticoid receptor signaling. Toxicol Rep. doi:10.1016/j.toxrep.2025.102053 2025;14:102053

*#Morris MT, Duncan BD, Piazuelo MB, Olfert IM, Xu X, Hussain S, Peek RM, Busada JT. Chronic cigarette smoke exposure masks pathological features of Helicobacter pylori infection while promoting tumor initiation. Cancer Prevention Research. 2025. doi: 10.1158/1940-6207.CAPR-24-0378.

#Selected for journal cover image

*Commentary: Kinoshita H, Guodong L, Hayakawa Y. Gastric Cancer Origins: Stem Cells, Metaplasia, and Environmental Interactions. Cancer Prevention Research. 2025. 10.1158/1940-6207.CAPR-25-0072

*Khadka S, Dziadowicz SA, Xu X, Wang L, Hu G, Carrero JA, DiPaolo RJ, Busada JT. Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity. Am J Physiol Gastrointest Liver Physiol. Epub 20240723. doi: 10.1152/ajpgi.00114.2024. 2024.

*Commentary: Bimczok D. Immune-enhancing effects of endogenous glucocorticoids on gastric macrophages contribute to the development of gastric inflammation and metaplasia. Am J Physiol Gastrointest Liver Physiol. DOI: https://doi.org/10.1152/ajpgi.00299.2024. 2024.

Druffner SR, Venkateshwaraprabu S, Khadka S, Duncan BC, Morris MT, Sen-Kilic E, Damron FH, Liechti GW, Busada JT. Comparison of gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis colonization in mice. Microbiol Spectr. 2024;12(6):e0001524.

Khadka S, Druffner SR, Duncan BC, Busada JT. Glucocorticoid regulation of cancer development and progression. Front Endocrinol. 2023. 14:1161768. DOI:10.3389/fendo.2023.1161768.

Busada JT*, Kadka S, Peterson KN, Druffner SR, Stumpo DJ, Zhou L, Cidlowski JA, Blackshear PJ. Tristetraprolin prevents gastric metaplasia in mice by suppressing pathogenic inflammation. Cell and Mol Gastro Hepatol. 2021. DOI:https://doi.org/10.1016/j.jcmgh.2021.07.015

*Corresponding author

Busada JT*, Peterson KN, Khadka S, Xu X, Oakley RH, Cook DN, Cidlowski JA*. Glucocorticoids and Androgens Protect from Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation. Gastroenterology. DOI: 10.1053/j.gastro.2021.04.075. 2021.

*Co-corresponding author

Kirsanova O, Renegar RH, Busada JT, Serra ND, Harrington EV, Johnson TA, Geyer CB. The rapamycin analog Everolimus reversibly impairs male germ cell differentiation and fertility in the mouse. Biol Reprod. 103(5):1132-1143. 2020.

Chung Nien Chin S, O'Connor L, Scurr M, Busada JT, Graham A, Alipour Talesh G, Tran C, Sarkar S, Minamoto M, Giraud A, Cidlowski J, Sutton P, and Menheniott T. Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer. Am J Physiol Gastrointest Liver Physiol. 319(2): G175-188. 2020.

Diaz-Jimenez DO, Petrillo MG, Busada JT, Hermosa MA, Cidlowski JA. Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4. J Biol Chem. 295(10): 3213-3227. 2020.

Busada JT, Ramamoorthy S, Cain, DW, Xu X, Cook DN, Cidlowski JA. (2019) Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. J Clin Invest. 129(3): 1345-1358. 2019.

Oakley RH, Ramamoorthy S, Foley JF, Busada JT, Lu NZ, Cidlowski JA. (2018) Glucocorticoid receptor isoform-specific regulation of development, circadian rhythm, and inflammation in mice. FASEB J. 32(10):5258-5271. 2018.

Busada JT and Cidlowski JA. Mechanisms of glucocorticoid action during development. Curr Top in Dev Biol. 125:147-170. 2017.

Busada JT, Velte EK, Serra ND, Cook KK, Niedenberger BA, Willis WD, Goulding EH, Eddy EM, Geyer CB. Rhox13 is required for quantitatively normal first wave of spermatogenesis in mice. Reproduction. 152(5): 379-388. 2016.

Busada JT, Geyer CG. The role of retinoic acid (RA) in spermatogonial differentiation. Biol Reprod, 94(1): 10-20. 2016.

Busada JT, Chappell VA, Niedenberger BA, Kaye EP, Keiper BD, Hogarth CA, and Geyer CB. Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse. Dev Biol, 397(1): 140-149. 2015.

Niedenberger BA, Busada JT, Geyer CB. Marker expression reveals heterogeneity of spermatogonia in the neonatal mouse testis. Reproduction, 149(4): 329-338. 2015.

Busada JT, Kaye EP, Renegar RH, and Geyer CB. Retinoic acid induces multiple hallmarks of the prospermatogonia-to-spermatogonia transition in the neonatal mouse. Biol Reprod, 90(3): 64-75. 2014.

Chappell VA, Busada JT, Keiper BD, and Geyer CB. Translational activation of developmental mRNAs during neonatal testis development. Biol Reprod 89(3): 61-71. 2013.